Around 10 000 miners will go on strike at Freeport-McMoran's Grasberg mine following a series of fatal accidents.
Earlier this month more than 500 workers blockaded the mine in protest after five workers were killed and one seriously injured in two separate accidents at the site.
Last month four workers were killed in a vehicle accident when an LV carrying nine passengers collided with a haulpack at Grasberg, in the open pit, killing four out of five of the light vehicle’s occupants.
The incident came only a fortnight after one miner was killed, and another injured, in a rockfall underground.
These fatal incidents were just one year after a major collapse underground trapped and killed 28 men.
"Anger among workers has peaked after a series of incidents at Freeport," the region's union official Albar Sabang told AFP.
He added that they are blaming management for the safety incidents, as the operation shifts from an open cut to an underground mine.
This latest major work stoppage comes after 70% of the workforce went on strike for three months due to wage disputes.